Triglyceride-Glucose Index Linked to Coronary Artery Disease Severity
A study found that higher triglyceride-glucose index levels correlate with increased coronary artery stenosis severity in patients undergoing angiography, suggesting its potential as a prognostic marker for cardiovascula
Cardiovascular disease remains a leading cause of mortality globally, with coronary heart disease representing the primary contributor to chronic disease-related deaths. Researchers investigated whether the triglyceride-glucose (TyG) index could serve as an independent prognostic marker for cardiovascular outcomes by examining its association with disease severity.
The study included 861 patients diagnosed with coronary heart disease who underwent coronary angiography between June 2022 and June 2024 at the Fourth Affiliated Hospital of Harbin Medical University. Participants were categorized into three groups based on Gensini scores derived from angiographic images, representing low, moderate, and high stenosis severity. Comprehensive data including demographics, laboratory findings, and medical history were collected from medical records.
Multivariate logistic regression analysis revealed that TyG levels differed significantly between mild and severe stenosis groups (p = 0.0021) and between moderate and severe groups (p = 0.0173). The TyG index was significantly associated with coronary stenosis, with an odds ratio of 1.591 (95% confidence interval: 1.237–1.866). After adjusting for confounding factors including age, sex, diabetes, and hypertension, individuals in higher TyG quartiles exhibited increased odds ratios for severe coronary stenosis compared to the reference group.
These findings indicate that the TyG index is positively associated with the extent of coronary artery stenosis and may serve as an indicator of atherosclerosis severity. The study suggests potential utility in risk stratification within clinical settings, though further validation is required before routine application.
This research provides evidence supporting the TyG index as a potential biomarker for cardiovascular risk assessment. However, results should be interpreted with caution due to the observational nature of the study and the specific population characteristics. The authors emphasize that these findings do not constitute medical advice or clinical recommendations for individual patients.