Pharmacist-Led Medication Therapy Management Improving Adherence in Type 2 Diabetes: Case Report
Poor medication adherence is a major challenge in healthcare for patients with type 2 diabetes mellitus, particularly those with long disease duration and complex therapeutic regimens. This case report describes the appl
Medication nonadherence remains a significant barrier to effective glycemic control in patients with type 2 diabetes mellitus (T2DM). In clinical research contexts, understanding how structured interventions influence adherence patterns is essential for optimizing metabolic outcomes. This case report examines the implementation of pharmacist-led medication therapy management (MTM) within a patient exhibiting severe nonadherence and multiple comorbidities.
The study involved a 76-year-old female with a 30-year history of T2DM complicated by diabetic peripheral neuropathy, hypertension, hyperlipidemia, hepatic steatosis, coronary atherosclerosis, and severe osteoporosis. The patient presented with poor glycemic control and frequent missed doses, irregular glucose monitoring, and forgotten weekly semaglutide injections. A clinical pharmacist conducted comprehensive MTM, including a full medication review, patient education, systematic medication and blood glucose monitoring, development of an optimized treatment plan in collaboration with the medical team, and ongoing follow-up.
After 3 months, glycemic control improved significantly, with fasting blood glucose at 7.6 mmol/L, postprandial glucose at 10.2 mmol/L, and glycated hemoglobin (HbA1c) at 7.3%. The Medication Adherence Report Scale-5 (MARS-5) score increased from 8 to 21, and no severe hypoglycemic events or other adverse drug reactions occurred during hospitalization or follow-up.
These findings suggest that pharmacist-led MTM can effectively improve medication adherence and clinical outcomes in patients with complex therapeutic regimens. However, this single case report does not establish causality or generalizability across diverse patient populations. Further research is required to determine the efficacy of such interventions in broader cohorts.